Publicaciones

Authors: Jeimy Blanco Barrantes , Eduviges Bustos Araya , Arlene Loría Gutiérrez


Summary: The aim of this study is to determine the natural medicinal products regulatory status of the main health authorities worldwide, to be used as a basis of improvement and optimization of legislation.

 

If you want more information about this publication you can send an e-mail to jeimy.blanco@ucr.ac.cr




Authors: Osvaldo Vega , Juan J. Araya , Max Chavarría , Erick Castellón


Summary: For the design of antibacterial materials comprising hybrid silica-containing plant oils capable of performing a controlled release of essential oil components, tests of lemongrass, citronella, basil, rosemary, eucalyptus, tea tree, lavander, clove and cinnamon against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Micrococcus luteus showed the essential oil of cinnamon to have the greatest antimicrobial activity. This work has produced the first application of hybrid organic-inorganic silicas containing an essential oil for the design of antibacterial materials.

 

If you want more information about this publication you can send an e-mail to juan.arayabarrantes@ucr.ac.cr




Authors: Luis Jiménez Herrera , Arlene Loría Gutiérrez , Gustavo Rojas Céspedes


Summary: The aim of this qualitative study was to know the opinion of active students, teachers, graduates, administrative staff and other students who left the pharmacy degree. The bio-psychosocial dimensions along with academic aspects are reported as the main causes of the prolongation of studies. The most important factors are related to students, teachers, student-teacher duo and the academic enviroment. It was shown that the causes which prolong the retention of students in the career is a multifaceted problem, where academics, curriculum and pedagogy are categories involved.

 

If you want more information about this publication you can send an e-mail to luis.jimenezherrera@ucr.ac.cr




Authors: Alfonso Pereira Céspedes , Catalina Lizano Barrantes , Luis Esteban Hernández Soto


Summary: The Minor Illness Service has specific characteristics according to the country. Knowing them improves pharmacist's decision-making. The aim of this study is to characterize the Minor Illness Service inquires in order to build the first national profile. During two months, it was carried out a cross-sectional multicenter pilot study in 30 community pharmacies in Costa Rica metropolitan area.

 

 If you want more information about this publication you can send an e-mail to: alfonso.pereiracespedes@ucr.ac.cr




Authors: Sandra Badilla Chaves , Jonathan Pérez Rocha , Sandra Hernández Salon , Nien Tzu Weng Wang , Jessica Morera Huertas


Summary: Different literature suggests that cannabis use is a major problem for public health. Cannabis, through its illegal nature, reaches its users without complying with any suitable standards of growth, storage,  processing and transport, which may generate diverse pollutants which can be chemical, physical or microbial. The presence of microbial pollutants is a risk for the user's health., especially in patients whose immune system is compromised. In Costa Rica there are no studies on the presence of microbial pollutants in commercialized cannabis, which is why the aim of this study was to establish the presence of the aforementioned pollutants in cannabis samples seized in six regions of Costa Rica territory and to relate this fact to risks for the health of its consumers.

 

If you want more information about this publication you can send an e-mail to nien-tzu.weng@ucr.ac.cr




Authors: Nils Ramirez Arguedas , Esteban González Mora , Jessica Morera Huertas , Gustavo Carazo Berrocal , Lidiette Fonseca González


The method was validated by ultraviolet spectrophotometry for the determination of levofloxacin 500 mg tablets using dissolution profiles to establish therapeutic equivalence. The parameters were satisfactory according to accuracy and precision in a linear range between 2,0 μg/mL and 8.0μg/mL. 

If you want more information about this publication you can send an e-mail to nils.ramirez@ucr.ac.cr




Authors: Olga Baudrit , Eleaneth Baltodano , Luis Jiménez


Summary: The objective of this work was to evaluate the fractionation of tablets in halves, performed with three methods and applied to ten medicines used in pathologies of epidemiological relevance in Costa Rica.    

 

If you want more information about this publication you can send an e-mail to eleaneth.baltodano@ucr.ac.cr




Authors: José Miguel Chaverri Fernández , Sergio García Chaves , Angie Ortiz Ureña , José Pablo Díaz Madriz , Jeimy Alvarado Leitón , Luis David Garro Zamora , María Laura Arias Echandi


Summary: Currently, there is a defined group of drugs, previously established by the Food and Drug Administration (FDA), that requires pharmacogenomic tests, due to possible polymorphism in the cytochromes that metabolizes them, leading to a potential modification of their pharmacokinetical and/or pharmacodynamical properties, and therefore their dosage. The main objective of this study was to determine the frequency if two single-nucleotide polymorphism (SNP) for CYP2D6 cytochrome, related to a poor metabolizer phenotype in a group of adults in Costa Rica.

 

If you want more information about this publication you can send an e-mail to jose.chaverri@ucr.ac.cr




Authors: German Madrigal Redondo , Rolando Vargas Zúñiga , Gustavo Carazo Berrocal , Nils Ramírez Arguedas


Summary: This study aimed to identify the polymorphic crystalline for of Etoricoxib raw material, a non-steroidal anti-inflammatory drug (NSAIDs) selective inhibitor of cyclooxygenase 2 (COX2) enzyme widely used in the present, which was done through four different instrumental analytical techniques: X-ray, diffractometry, differential scanning calorimetry, thermogravimetry and infrared spectroscopy, comparing and studying the results obtained from the analysis with those found in the literature. Using the data obtained with these four techniques it was demonstrated that the study sample exists predominantly in the anhydrous Etoricoxib form.

 

If you want more information about this publication you can send an e-mail to german.madrigal@ucr.ac.cr

 




Authors: German Madrigal Redondo , Rolando Vargas Zúñiga , Gustavo Carazo Berrocal , Nils Ramírez Arguedas


The objetive of the study was to formulate a cream based on hot springs with renewable natural resources, cosmetic features, and high in content of minerals and not physicochemically unstable due to this composition.

 


If you want more information about this publication you can send an e-mail to german.madrigal@ucr.ac.cr




Authors: Jonathan Parra , Pedro M. García-Barrantes , Gerardo Rodríguez , Beatriz Badilla


Summary:  The aim of this study is to characterize a chamomile (Matricaria recutita)  tincture through chemometric analysis of chromatographic data in order to establish quality parameters of its production.

 

If you want more information about this publication you can send an e-mail to jonathan.parra@ucr.ac.cr




Authors: German Madrigal Redondo , Rolando Vargas Zúñiga , Gustavo Carazo Berrocal , Nils Ramírez Arguedas


Despite of its reachness, the mineral resources of Costa Rica are poorly physicochemically characterized, furthermore, they have been studiend by their physicall characteristics and chemical composition, which allow their use in therapeutic and cosmetic applications. 

 

If you want more information about this publication you can send an e-mail to german.madrigal@ucr.ac.cr

 




Authors: Olga Baudrit Carillo , Luis Jiménez Herrara


To elaborate the pediatric medicines the specifics of this population must be considered. Powder papers as extemporaneous formulations may be an option to provide dosing flexibility. The main objective of this research was to evaluate the quality of powder papers in its manual preparation stages and during the 60 days of storage. The results shown that a smaller than expected mass of tablets was distributed for the 40 papers at each formulation. 

 

If you want more information about this publication you can send an e-mail to luis.jimenezherrera@ucr.ac.cr




Authors: Olga Baudrit Carrillo , Eleaneth Baltodano , Luis Jiménez Herrera , Jeimy Blanco , María Fernanda Jiménez


To elaborate the pediatric medicines the specifics of this population must be considered. Powder papers as extemporaneous formulations may be an option to provide dosing flexibility. The main objective of this research was to evaluate the quality of powder papers in its manual preparation stages and during the 60 days of storage. The results shown that a smaller than expected mass of tablets was distributed for the 40 papers at each formulation. 

 

If you want more information about this publication you can send an e-mail to eleaneth.baltodano@ucr.ac.cr

 




Authors: Olga Baudrit , Eleaneth Baltodano , Luis Jiménez


Summary: Not always people receive the just dose of active ingredient required for his health problem. To obtain success in pharmacology treatment, sometimes the physicians prescribe drugs in a dose that is impossible obtain in the market because this specific strength does not exist in the pharmaceutical form that they proposed. This is the case of some tablets, which need to be divided to achieve this objetive. Several reasons are to justify the need to split pills, since there exist some consequences of this act in different contexts. More research is required in Costa Rica, Central America to know the magnitude of the actual situation in this topic.

 

If you want more information about this publication you can send an e-mail to eleaneth.baltodano@ucr.ac.cr




Authors: Sandra Badilla Chaves , Mijail Rojas-Carvajal , Jaime Fornaguera , Juan C. Brenes , María F. Calvo


St. John’s wort (Hypericum perforatum, HP) is one of the most used herbal medicines. Here we investigated the putative antidepressive- and anxiolytic-like effects of HP, by using a wellvalidated rat model of anxiety and depression based on chronic stress.




Authors: Juan J. Araya , Kelly Kindscher , Barbara N. Timmermann


Summary: Phytochemical investigationof the obove-ground biomass of Asclepias sullivantii L. (Asclepiadaceae) affored six new pregnane glycosides, named sullivantosides A-F (1-6). The structure of 1-6 were elucidated through a variety of spectroscopic and spectrometric techniques (1D and 2D NMR; HRESIMS). To the best of our knowledge, this work represents the first phytochemical study of this species.

 

If you want more information about this publication you can send an e-mail to juan.arayabarrantes@ucr.ac.cr




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